MyBioSource.com's Phospho-ACK1 (Y826) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Dot Blot, and ELISA. The Phospho-ACK1 (Y826) Antibody was generated using ACK, ACK1, Pyk1, and TNK2 as the antigen and it reacts with Human, Mouse, and Rat.
Description
ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway